DAVID syndrome, having variable endocrine and immune deficiencies:
DAVID syndrome is a rare condition combining anterior pituitary hormone deficiency with common variable immunodeficiency. NFKB2 mutations have recently been identified in patients with ACTH and variable immunodeficiency. A similar mutation was previously found in Nfkb2 in the immunodeficient Lym1 mouse strain, but the effect of the mutation on endocrine function was not evaluated.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411703/
