Primary Immunodeficiency (PI) causes children and adults to have infections that come back frequently or are unusually hard to cure. 1:500 persons are affected by one of the known Primary Immunodeficiencies. If you or someone you know is affected by two or more of the following Warning Signs, speak to a physician about the possible presence of an underlying Primary Immunodeficiency.
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- Four or more new ear infections within one year.
- Two or more serious sinus infections within one year.
- Two or more months on antibiotics with little effect.
- Two or more pneumonias within one year.
- Failure of an infant to gain weight or grow normally.
- Recurrent, deep skin or organ abscesses.
- Persistent thrush in mouth or fungal infection on skin.
- Need for intravenous antibiotics to clear infections.
- Two or more deep-seated infections including septicaemia.
- A family history of PI.
 
Information provided courtesy of Jeffrey Modell Foundation.